Dipeptide and cyclic-dipeptide secondary metabolites derived from Streptomyces: molecular structure and therapeutic applications
Di & Cyclic-peptide secondary metabolites of Streptomyces
Keywords:
antibacterial , antimicrobial peptides, dipeptides , StreptomycesAbstract
Purpose: In this review, we focus specifically on dipeptides and cyclic dipeptides derived from Streptomyces, exploring their structural diversity, biosynthesis pathways, and potential therapeutic applications.
Methods: This review is prepared with collection of many literatures about antimicrobial peptides from Streptomyces.
Results: Streptomyces are prolific producers of secondary metabolites and antibiotics, contributing significantly to pharmacology and industry fields. They are widely distributed in various environments. These gram-positive strains are generally non-pathogenic. While many antibiotics originate from Streptomyces, ongoing research continues to unveil novel metabolites with diverse biological activities, including anticancer, antibacterial properties, and others whose functions remain undiscovered. Some of these peptides like albonoursin and alahopsin are self-assembled dipeptides.
Conclusion: Application, design and engineering of dipeptides and cyclic dipeptides from Streptomyces could be a novel method in development of therapeutic purposes, especially for reduction of human toxicity.
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Copyright (c) 2025 Fatemeh Sadat Ghoreishi, Fatemeh Yousef-Saber (Author); Giti Emtiazi; Fatih Tarlak (Author)
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